Protein Details: Chloride channel CLIC-like protein 1

Protein ID

ICDB_Pro_1410

Protein Name

Chloride channel CLIC-like protein 1

Gene Name

CLCC1; KIAA0761; MCLC

Organism

Homo sapiens (Human)

Length

551 amino acids

AlphaFoldDB

AF-Q96S66-F1-model_v4.pdb

Function

Seems to act as a chloride ion channel . Plays a role in retina development .

Sequence

MLCSLLLCECLLLVAGYAHDDDWIDPTDMLNYDAASGTMRKSQAKYGISGEKDVSPDLSCADEISECYHKLDSLTYKIDECEKKKREDYESQSNPVFRRYLNKILIEAGKLGLPDENKGDMHYDAEIILKRETLLEIQKFLNGEDWKPGALDDALSDILINFKFHDFETWKWRFEDSFGVDPYNVLMVLLCLLCIVVLVATELWTYVRWYTQLRRVLIISFLFSLGWNWMYLYKLAFAQHQAEVAKMEPLNNVCAKKMDWTGSIWEWFRSSWTYKDDPCQKYYELLLVNPIWLVPPTKALAVTFTTFVTEPLKHIGKGTGEFIKALMKEIPALLHLPVLIIMALAILSFCYGAGKSVHVLRHIGGPESEPPQALRPRDRRRQEEIDYRPDGGAGDADFHYRGQMGPTEQGPYAKTYEGRREILRERDVDLRFQTGNKSPEVLRAFDVPDAEAREHPTVVPSHKSPVLDTKPKETGGILGEGTPKESSTESSQSAKPVSGQDTSGNTEGSPAAEKAQLKSEAAGSPDQGSTYSPARGVAGPRGQDPVSSPCG

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Retinitis Pigmentosa and Retinitis

Location

Expressed in the retina of the eye; with extensive expression in the lamina cribrosa; optic nerve; ganglion cell layer; inner nuclear layer; outer nuclear layer and retinal pigment epithelium

DOI ID

10.1074/jbc.m100366200; 10.1093/dnares/5.5.277; 10.1038/nature04727; 10.1101/gr.2596504; 10.1016/j.cell.2006.09.026; 10.1021/pr070152u; 10.1073/pnas.0805139105; 10.1021/ac9004309; 10.1126/scisignal.2000475; 10.1186/1752-0509-5-17; 10.1126/scisignal.2001570; 10.1021/pr300630k; 10.1016/j.jprot.2013.11.014; 10.1038/s41467-019-12816-z; 10.1007/s00439-005-0054-4; 10.1371/journal.pgen.1007504

RefSeq

NP_001041675.1 [Q96S66-1]; NP_001265131.1 [Q96S66-3]; NP_001265132.1 [Q96S66-4]; NP_055942.1 [Q96S66-2];